Welcome to the Lewis Lab
Chromatin orchestrates the regulation of genomic DNA accessibility for gene transcription by integrating a diverse array of biochemical signals.
Our research focuses on elucidating the biochemical mechanisms that establish and maintain silent chromatin, commonly referred to as heterochromatin. Proper maintenance of silent chromatin is essential for preserving cellular identity by ensuring the repression of genes specific to alternative lineages. Disruption of these processes can result in developmental abnormalities or contribute to tumorigenesis.
To investigate these mechanisms, we employ a multidisciplinary approach that integrates highly purified biochemical assays, proteomic and genomic analyses, and genetic screens. Through this work, we aim to advance our understanding of chromatin biology and its implications for development and disease.
Post-doctoral positions available!
Join our accomplished team in the Lewis lab! We have a diverse range of research opportunities available, including areas such as heterochromatin biochemistry, gene regulation, genomics, and cancer biology.
We are looking for candidates who possess a Ph.D. in molecular biology, cell biology, biochemistry, genetics, bioinformatics, or a related field. The ideal candidate will have a strong record of scientific research, productivity, and creativity. Strong communication skills, both oral and written, are a must. Candidates with a background in bioinformatics and biochemistry are particularly encouraged to apply.
To apply, please submit a cover letter, CV, and contact information for at least three references. We look forward to reviewing your application.
